Search results for " mean difference"

showing 10 items of 24 documents

Denosumab for bone health in prostate and breast cancer patients receiving endocrine therapy? A systematic review and a meta-analysis of randomized t…

2019

Highlights • Hormonal receptors positive breast tumor and prostate cancer are managed with endocrine therapies. • Endocrine therapies designed for breast and prostate cancer are often associated to serious adverse skeletal related events, such fractures. • Denosumab is a monoclonal anti-body binding RANKL which acts as inhibitor of osteoclasts activity, thus increasing bone mass. • Denosumab was showed to strongly prevent hormonal therapies-related skeletal issues. • Denosumab administration results safe in bone mass increase and reduction of fractures risk.

0301 basic medicineOncologyRCTs randomized clinical trialrandomized clinical trialslcsh:Diseases of the musculoskeletal systemSettore MED/06 - Oncologia MedicaOsteoporosisBMD bone mass densityReview Articleandrogen deprivation therapyADTlaw.inventionAndrogen deprivation therapyProstate cancerhazard ratio0302 clinical medicineRandomized controlled triallawHRMedicineBreastSAEsCancerProstateRANKLCIMD mean differencelcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogensRCTs randomized clinical trialsDenosumabOncology030220 oncology & carcinogenesisSAEs serious adverse eventsDenosumabmean differencemedicine.drugmedicine.medical_specialtylcsh:RC254-28203 medical and health sciencesBreast cancerRANKL receptor activator of nuclear factor-kB ligandBMDInternal medicineAdverse effectADT androgen deprivation therapyRCTsbusiness.industryMDmedicine.diseaseHR hazard ratioHormonereceptor activator of nuclear factor-kB ligandDiscontinuationCI confidence interval030104 developmental biologyFractureconfidence intervalADT androgen deprivation therapy; BMD bone mass density; Breast; CI confidence interval; Cancer; Denosumab; Fracture; HR hazard ratio; Hormone; MD mean difference; Prostate; RANKL receptor activator of nuclear factor-kB ligand; RCTs randomized clinical trials; SAEs serious adverse eventsserious adverse eventsbone mass densitylcsh:RC925-935businessJournal of Bone Oncology
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Lipoprotein(a) Levels in Patients With Abdominal Aortic Aneurysm

2016

Circulating markers relevant to the development of abdominal aortic aneurysm (AAA) are currently required. Lipoprotein(a), Lp(a), is considered a candidate marker associated with the presence of AAA. The present meta-analysis aimed to evaluate the association between circulating Lp(a) levels and the presence of AAA. The PubMed-based search was conducted up to April 30, 2015, to identify the studies focusing on Lp(a) levels in patients with AAA and controls. Quantitative data synthesis was performed using a random effects model, with standardized mean difference (SMD) and 95% confidence interval (CI) as summary statistics. Overall, 9 studies were identified. After a combined analysis, patie…

0301 basic medicinemedicine.medical_specialtymacromolecular substances030204 cardiovascular system & hematologyGastroenterology03 medical and health sciences0302 clinical medicineInternal medicineMedicineIn patientcardiovascular diseasesbiologybusiness.industryLipoprotein(a)medicine.diseaseConfidence intervalAbdominal aortic aneurysmSurgery030104 developmental biologyStrictly standardized mean differenceMeta-analysiscardiovascular systembiology.proteinBiomarker (medicine)Cardiology and Cardiovascular MedicinebusinessLipoproteinAngiology
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The smokeless tobacco habit and DNA damage: A systematic review and meta-analysis.

2018

Background The aim of this systematic review was to evaluate the frequency of micronuclei or other DNA damage in the oral mucosa of adults that have smokeless tobacco habits compared to adults that not have these habits. Material and Methods We searched PubMed, Scopus, Web of Science, LILACS, BBO and Cochrane Library and SIGLE. We also surveyed gray literature. We included only clinical trials that compare the frequency of micronuclei or other DNA damage in the oral mucosa of adults that have smokeless tobacco habits compared to adults that not have these habits. Quality assessments of the selected trials were evaluated by two independent reviewers, using the Effective Public Health Practic…

Adultmedicine.medical_specialtyTobacco SmokelessDatabases FactualMEDLINEletterReviewCochrane LibraryHabits03 medical and health sciences0302 clinical medicineInternal medicineTobaccomedicineHumansGeneral DentistryMicronucleus TestsOral Medicine and Pathologybusiness.industrySmokingMouth Mucosa030206 dentistry:CIENCIAS MÉDICAS [UNESCO]Confidence intervalClinical trialOtorhinolaryngologySmokeless tobaccoStrictly standardized mean differenceMeta-analysisMicronucleus testUNESCO::CIENCIAS MÉDICASMouth NeoplasmsSurgeryPublic HealthbusinessDNA DamageMedicina oral, patologia oral y cirugia bucal
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Associations between personality, sports participation and athletic success. A comparison of Big Five in sporting and non-sporting adults

2018

Abstract The present study investigates whether the Big Five personality traits are different among diverse sports populations. A sample of 881 male athletes and non-athletes completed a self-report questionnaire measuring their personality traits. The Exploratory Structure Equation Modeling (ESEM) approach is adopted to test measurement invariance and mean differences among groups. The results indicate that athletes who had experienced the most success in their sport scored higher than non-athletes in each personality dimension of the Big Five, with the exception of openness, while less successful athletes scored higher than non-athletes only in extraversion and agreeableness. The more suc…

AgreeablenessSettore M-PSI/01 - Psicologia GeneraleBig Five personality factormedia_common.quotation_subjectSport succe050109 social psychologyIndividual and team sportHierarchical structure of the Big Fivesports participation and athletic success050105 experimental psychologyDevelopmental psychologywith the exception of opennessOpenness to experiencePersonality0501 psychology and cognitive sciencesBig Five personality traitsconscientiousnessGeneral Psychologymedia_commonBig Five personality factorsBig Five personality factors Exploratory structural equation modeling Sport participation Sport success Individual and team sportExtraversion and introversionbiologySport successAthleteswhile less successful athletes scored higher than non-athletes only in extraversion and agreeableness. The more successful athletes showed higher agreeableness05 social sciencesExploratory structural equation modelingConscientiousnessbiology.organism_classificationThe present study investigates whether the Big Five personality traits are different among diverse sports populations. A sample of 881 male athletes and non-athletes completed a self-report questionnaire measuring their personality traits. The Exploratory Structure Equation Modeling (ESEM) approach is adopted to test measurement invariance and mean differences among groups. The results indicate that athletes who had experienced the most success in their sport scored higher than non-athletes in each personality dimension of the Big Five with the exception of openness while less successful athletes scored higher than non-athletes only in extraversion and agreeableness. The more successful athletes showed higher agreeableness conscientiousness and emotional stability than the less successful athletes. Individual-sport athletes were found to be more energetic and open than team-sport athletes. The current findings help clarify the relationships between personality traits sports participation and athletic success.and emotional stability than the less successful athletes. Individual-sport athletes were found to be more energetic and open than team-sport athletes. The current findings help clarify the relationships between personality traitsPsychologyhuman activitiesThe present study investigates whether the Big Five personality traits are different among diverse sports populations. A sample of 881 male athletes and non-athletes completed a self-report questionnaire measuring their personality traits. The Exploratory Structure Equation Modeling (ESEM) approach is adopted to test measurement invariance and mean differences among groups. The results indicate that athletes who had experienced the most success in their sport scored higher than non-athletes in each personality dimension of the Big FiveSport participation
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Meta-analysis of the correlation between serum uric acid level and carotid intima-media thickness

2021

Objective Recently, increasing epidemiological evidence has shown that there is a correlation between serum uric acid level (SUA) and carotid intima-media thickness (CIMT). This paper explored the relationship between them through meta-analysis. Methods PubMed, Cochrane Library, EMBASE, Web of Science and Google Scholar were searched to obtain literature. The keywords used to retrieve the literature were carotid intima thickness, intima-media thickness, carotid atherosclerosis, carotid stenosis, carotid artery, uric acid, blood uric acid, and hyperuricaemia. The retrieval time was from the establishment of the database through July 2020. Stata15.0 and RevMan5.3 software were used for stati…

Carotid Artery DiseasesPublication EthicsType 2 diabetes030204 cardiovascular system & hematologyCardiovascular MedicineGastroenterologyVascular MedicineCarotid Intima-Media ThicknessGeographical Locationschemistry.chemical_compound0302 clinical medicineMathematical and Statistical TechniquesMedical ConditionsEndocrinologyMedicine and Health SciencesCarotid Stenosis030212 general & internal medicineResearch IntegrityMultidisciplinaryQStatisticsRMetaanalysisType 2 DiabetesChemistryCarotid ArteriesNeurologyCardiovascular DiseasesMeta-analysisPhysical Sciencescardiovascular systemMedicineResearch Articlemedicine.medical_specialtyChinaAsiaScience PolicyEndocrine DisordersScienceCerebrovascular DiseasesCardiologySubgroup analysisHyperuricemiaResearch and Analysis Methods03 medical and health sciencesInternal medicinemedicineDiabetes MellitusHumanscardiovascular diseasesStatistical Methodsbusiness.industryChemical CompoundsCardiovascular Disease Riskmedicine.diseaseAtherosclerosisConfidence intervalUric AcidIntima-media thicknesschemistryStrictly standardized mean differenceSample size determinationMetabolic DisordersPeople and PlacesUric acidbusinessAcidsMathematicsPLoS ONE
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What Is the Role of Minimally Invasive Mitral Valve Surgery in High-Risk Patients? A Meta-Analysis of Observational Studies

2016

Background. Minimally invasive valve surgery is related to certain better postoperative outcomes. We aimed to assess the role of minimally invasive mitral valve surgery in high-risk patients. Methods. A systematic literature review identified eight studies of which seven fulfilled criteria for metaanalysis. Outcomes for a total of 1,254 patients (731 were conventional standard sternotomy and 523 were minimally invasive mitral valve surgery) were submitted to meta-analysis using random effects modeling. Heterogeneity and subgroup analysis with quality scoring were assessed. The primary end point was early mortality. Secondary end points were intraoperative and postoperative outcomes and long…

Heart Valve Diseases030204 cardiovascular system & hematologyGlobal HealthWMD weighted mean differencelaw.inventionPostoperative Complications0302 clinical medicineRisk FactorslawMitral valveCPB cardiopulmonary bypaStrokeHeart Valve Prosthesis ImplantationMedicine (all)Abbreviations and Acronyms AF atrial fibrillation; CI confidence interval; CPB cardiopulmonary bypass; MIMVS minimally invasive mitral valve surgery; OR odds ratio; PRC packed red cells; ST sternotomy; WMD weighted mean difference; Global Health; Heart Valve Diseases; Heart Valve Prosthesis Implantation; Humans; Minimally Invasive Surgical Procedures; Mitral Valve; Postoperative Complications; Risk Factors; Survival Rate; Observational Studies as Topic; Risk Assessment; Cardiology and Cardiovascular Medicine; Surgery; Pulmonary and Respiratory Medicine; Medicine (all)Atrial fibrillationSurvival RateHeart Valve DiseaseObservational Studies as Topicmedicine.anatomical_structureCardiologyMitral ValveCardiology and Cardiovascular MedicineHumanPulmonary and Respiratory Medicinemedicine.medical_specialtyAbbreviations and Acronyms AF atrial fibrillationSubgroup analysisRisk Assessment03 medical and health sciencesST sternotomyInternal medicinePRC packed red cellmedicineCardiopulmonary bypassHumansMinimally Invasive Surgical ProceduresSurvival ratebusiness.industryCI confidence intervalRisk FactorMinimally Invasive Surgical ProcedureOdds ratioOR odds ratiomedicine.diseaseConfidence intervalSurgeryMIMVS minimally invasive mitral valve surgery030228 respiratory systemSurgeryPostoperative ComplicationbusinessThe Annals of Thoracic Surgery
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Discover cervical disc arthroplasty versus anterior cervical discectomy and fusion in symptomatic cervical disc diseases: A meta-analysis.

2016

OBJECTIVE:Symptomatic cervical disc disease (SCDD) is a common degenerative disease, and Discover artificial cervical disc, a new-generation nonconstrained artificial disk, has been developed and performed gradually to treat it. We performed this meta-analysis to compare the efficacy and safety between Discover cervical disc arthroplasty (DCDA) and anterior cervical discectomy and fusion (ACDF) for SCDD. METHODS:An exhaustive literature search of PubMed, EMBASE, and the Cochrane Library was conducted to identify randomized controlled trials that compared DCDA with ACDF for patients suffering SCDD. A random-effect model was used. Results were reported as standardized mean difference or risk …

MalePhysiologymedicine.medical_treatmentSensory Physiologylcsh:MedicineAnterior cervical discectomy and fusionIntervertebral Disc DegenerationCochrane LibraryOssificationlaw.invention0302 clinical medicineMathematical and Statistical TechniquesRandomized controlled triallawMedicine and Health SciencesRange of Motion Articularlcsh:ScienceIntervertebral DiscRandomized Controlled Trials as Topic030222 orthopedicsProstheticsMultidisciplinaryMiddle AgedSensory SystemsTreatment OutcomeSomatosensory SystemResearch DesignMeta-analysisPhysical SciencesCervical VertebraeFemaleBone RemodelingRange of motionIntervertebral Disc DisplacementStatistics (Mathematics)DiskectomyResearch ArticleBiotechnologyAdultmedicine.medical_specialtyDrug Research and DevelopmentClinical Research DesignSurgical and Invasive Medical ProceduresResearch and Analysis MethodsArthroplasty03 medical and health sciencesMusculoskeletal System ProceduresmedicineHumansClinical TrialsStatistical MethodsPharmacologybusiness.industrylcsh:RBiology and Life SciencesPain SensationArthroplastyRandomized Controlled TrialsSurgeryAssistive TechnologiesStrictly standardized mean differenceRelative risklcsh:QMedical Devices and EquipmentAdverse EventsClinical MedicinebusinessPhysiological Processes030217 neurology & neurosurgeryMathematicsMeta-AnalysisNeurosciencePloS one
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Exercise for depression in older adults: a meta-analysis of randomized controlled trials adjusting for publication bias

2016

OBJECTIVE: To evaluate the antidepressant effects of exercise in older adults, using randomized controlled trial (RCT) data. METHODS: We conducted a meta-analysis of exercise in older adults, addressing limitations of previous works. RCTs of exercise interventions in older people with depression (≥ 60 years) comparing exercise vs. control were eligible. A random-effects meta-analysis calculating the standardized mean difference (SMD) (95% confidence interval [95%CI]), meta-regressions, and trim, fill, and fail-safe number analyses were conducted. RESULTS: Eight RCTs were included, representing 138 participants in exercise arms and 129 controls. Exercise had a large and significant effect on…

Malemedicine.medical_specialtylcsh:RC435-571Subgroup analysisReview Articlenot knownlaw.invention03 medical and health sciences0302 clinical medicinePhysical medicine and rehabilitationRandomized controlled triallawRisk Factorslcsh:PsychiatryMedicineHumans030212 general & internal medicineExerciseolder adultsAgedRandomized Controlled Trials as Topicpublication biasAged 80 and overDepressive Disorder Majorbusiness.industryAge FactorsPublication biasMiddle AgedConfidence intervalExercise Therapymeta-analysisPsychiatry and Mental healthTreatment OutcomeStrictly standardized mean differenceMeta-analysisdepressionPhysical therapyFemalebusinessAnaerobic exercise030217 neurology & neurosurgeryManagement of depressionBrazilian Journal of Psychiatry
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Effectiveness of Exergame Intervention on Walking in Older Adults: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

2020

Abstract Objective The objective of this review was to systematically evaluate the effectiveness of exergaming on walking in older adults. In addition, the aim was to investigate the relationship between the exergaming effect and age, baseline walking performance, exercise traits, technology used, and the risk of bias. Methods A literature search was carried out in the databases MEDLINE, CINAHL, CENTRAL, EMBASE, WoS, PsycInfo, and PEDro up to January 10, 2020. Studies with a randomized controlled trial design, people ≥60 years of age without neurological disorders, comparison group with other exercise or no exercise, and walking-related outcomes were included. Cochrane RoB2, meta-analysis, …

Malemedicine.medical_specialtymedicine.medical_treatmentMEDLINEPsychological interventionPhysical Therapy Sports Therapy and RehabilitationHealth PromotionWalkingPsycINFOCINAHLlaw.inventionRandomized controlled triallawHumansMedicineMuscle StrengthExerciseAgedRandomized Controlled Trials as TopicRehabilitationbusiness.industryAge FactorsExercise TherapyVideo GamesStrictly standardized mean differenceMeta-analysisPhysical therapyFemalebusinessAttitude to HealthPhysical Therapy
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The Effects of Tamoxifen on Plasma Lipoprotein(a) Concentrations: Systematic Review and Meta-Analysis

2017

Introduction: Tamoxifen is a selective estrogen receptor modulator widely used in the treatment of breast cancer. Tamoxifen therapy is associated with reduced circulating low-density lipoprotein cholesterol and increased triglycerides, but its effects on other lipids are less-well studied. Aims: We aimed to investigate the effect of tamoxifen on circulating concentrations of lipoprotein(a) (Lp(a)) through systematic review and meta-analysis of available randomized controlled trials (RCTs) and observational studies. Methods: This study was registered in the PROSPERO database (CRD42016036890). Scopus, Medline and EMBASE were searched from inception until 22nd March 2016 to identify studies in…

OncologySelective Estrogen Receptor Modulatorsmedicine.medical_specialtyRMTamoxifen; lipoprotein(a) concentration; circulation; treatmentBreast Neoplasms030204 cardiovascular system & hematologylaw.invention03 medical and health sciences0302 clinical medicineBreast cancerRandomized controlled triallawInternal medicineCell Line TumormedicineHumansPharmacology (medical)QDRandomized Controlled Trials as Topictreatmentbusiness.industrymedicine.diseaselipoprotein(a) concentrationConfidence intervalTamoxifenEndocrinologyStrictly standardized mean differenceSelective estrogen receptor modulator030220 oncology & carcinogenesisMeta-analysiscirculationFemaleSystematic ReviewbusinessTamoxifenmedicine.drugLipoproteinLipoprotein(a)
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